Tin-Tin Ho found world No 34 and host nation player Manika Batra too strong at the WTT Star Contender Goa as she went out in the last 64.
It was a three-game defeat for the England No 1 as she was once agai beaten by the opponent who knocked her out of the Tokyo Olympics in 2021.
Meanwhile, in the men’s doubles, Sam Walker & Tom Jarvis went out in the last 16 to Park Ganghyeon & Kang Dongsoo of South Korea.
It leaves Liam Pitchford as the only English representation in the event – he faces Simon Gauzy (WR 32) of France in the last 32 of the men’s singles at 9.50am UK time on Thursday on table 4.
Watch live on the WTT YouTube channel – click here to select the table number you want to watch
Round of 64
Manika Batra (IND) bt Ho 3-0 (11-4, 11-8, 11-5)
Round of 16
Park Ganghyeon & Kang Dongsoo (KOR) bt Walker & Jarvis 3-0 (11-6, 11-8, 14-12)